The relationship between Human Systems Integration and the meme presented below is in an indirect relationship. Human Systems Integration is the relationship between the human and the user operational environment and how the system is designed to that relationship. This relates to the meme because of the scene that is depicted between the user and the over-arching environment of the city in the background that is comparing to the system. It is best to provide utmost optimization for the system to continue a prospering relationship for the human and user operational environment.